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KMID : 0605620060130030178
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Journal of Korean Society of Biological Psychiatry
2006 Volume.13 No. 3 p.178 ~ p.189
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Relationship between Alcohol Withdrawal Symptoms and Dopaminergic Gene Polymorphisms(DRD2,DAT,COMT) in Alcohol Dependence Patients
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Choi Tai-Young
Lee Young-Sik
Han Doug-Hyun
Na Churl
Min Kyung-Jun
Kim Ho-Nam
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Abstract
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with DAT-9 gene allele. And The total score of CIWA-Ar scale in the subject without DAT-9 gene allele was significantly higher than in the subject with DAT-9 gene allele. COMT: The total score of CIWA-Ar scale in heterozygote was significantly higher than in homozygote.
Conclusions:Our results suggest the relationship between specific genetic factors and the withdrawal symptoms of alcohol dependent patients. As the candidate gene of the severity of alcohol withdrawal syndrome, DRD2 Taq1 gene was recommended.
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KEYWORD
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Alcohol Withdrawal, Gene Polymorphism, CIWA-Ar
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